Over the past six months, rimu has ~4X more commits to the project than I do, and then it is a steep drop off from there (other than a ton of individual css fixes by travis-jeans). So, it is not entirely a one person show, but it mostly is. Part of that is that rimu is just really quick. We will talk over an idea, and then he will implement it faster than I can even make the git branch.

You are using piefed, so in the web ui you can click the three dot menu and select the remind me option. This isn’t in the api though, so it wouldn’t be in a third-party app unless they implemented it separately.

Nothing to do with federation. piefed.zip decided not to make their modlog public. It’s an admin setting within piefed. IIRC, it isn’t an option in lemmy.

Oh man, give me a scientific issue any day of the week. I would much rather deal with some investigation rather than work on an IND, BLA, or MAA section to submit to an agency. I have tremendous respect for reg folks that can make sense of the agency guidance. Thank you for your service!

I work professionally in the field of pharmaceutical manufacturing, though mainly with liquid and lyophilized presentations. The issue talked about in this video, polymorphism and isomerization, would primarily just be an issue with drugs that are considered small molecules. Historically, that is most drugs…but that is changing as more and more other modalities are hitting the market.

Small molecules, especially in a dry powder, undergo lots of processes that would make cleaning with enough rigor to completely eliminate a polymorph extremely difficult. Things like milling, mixing, spray drying, and pressing are extremely energetic and intentionally disperse powder like crazy. The cleaning cycles for all this equipment are already extremely rigorous, often reducing contaminants to levels too low to measure and then undergoing sterilization cycles with vaporized hydrogen peroxide (VHP) between batches. However, when you are talking about autocatalysis like this, it only takes ppb-level contamination to propagate through the whole batch.

When you are talking about large molecules like biologics (antibodies, most vaccines, etc.), there are a whole bunch of other things that can go wrong, but not this. The most analogous thing I can think of would be a persistent viral contamination. Current good manufacturing practices (cGMP) should be able to alleviate this though, and it wouldn’t impact tech transfer to a different site like what happened in the video. Alternatively, I have worked on mAbs where each batch would measure the glycosylation state because it impacted activity. That is a post-translational modification process for that drug that some batches worked better than others, but we never really tracked down a root cause (before the program was killed).

Another case study that happened on a program I was working on was that we had a series of batches where the active ingredient (a mAb) was oxidized at a much higher rate than normal. Nothing about our process had changed, but it was a clear night/day difference that happened all of a sudden. After lots of testing and ruling things out, we managed to figure out that there were elevated levels of iron in our product. By sampling at each step of our process, we figured out that the iron was being introduced during two steps called bioburden reduction filtration and sterile filtration. You might notice that these are both unit operations where our drug passes through filter membranes (they were in fact the same filters). Ultimately, it turned out that the supplier of our filters had a contamination issue that impacted their filters from a certain lot and later. So, we were ultimately able to fix it, but I remember those reports being literally hundreds of pages of ruling stuff out before we finally figured out the root cause.

Hope that helps you feel better!

Also a former big fan of RIF and I found Boost a fairly easy transition.

There is an admin setting that requires a user to be logged in before viewing pages on the site. We keep that off normally, but we recently had it on for a couple of days because of over-aggressive scrapers.

I just checked in the admin panel and your user isn’t banned. It’s possible that you might be quite unlucky with a VPN exit node or something and are now on an IP that was previously subject to a ban. We tend to not use IP bans except in egregious cases, but those users also tend not to connect via their home connection.

Things you can try:

• Try clearing your browser cache for piefed.social. You want to remove any cookies that might be left in your browser from the site.
• If you are using a VPN try turning it off and clearing your browser cache. Basically trying to start fresh with a new IP address.
• If you aren’t using a VPN, try from a mobile device, third-party app, or one of our alternative frontends (photon, blorp)

Piefed does allow users the option to not federate their votes. So harvesting that data would mean needing local access to the infrastructure or snooping on traffic to/from your local instance.

The final vote came down to a very narrow margin between our top two vote-getters. If you are curious about the very close runner up (that I voted for), that was the opening song from “CITY The Animation” - “Hello” by Furui Riho.

Links:

• anime OP (animated, but edited down to 1:30): https://www.youtube.com/watch?v=10eZAXGuVT4
• Full MV: https://www.youtube.com/watch?v=JxyACq69HgA

It’s a great pick and one of my favorite vocaloid songs. Teto has been blowing up in the past year and Jamie Paige has put out some of Teto’s best stuff.

Just to be clear, I think Skavau is proposing an idea, not talking about a feature that currently exists within PIeFed.

Overall, more fine-grained roles and permissions are a recurring topic that has come up in discussions. That is both among the developers and with other instance admins. I think being able to make some users be able to take some actions like clean up/assign flair or edit wiki pages without being given all the moderator powers would be a big improvement.

The really hard part of this comes when you introduce federation. You both need to give a user the ability to do the thing and also allow other instances to recognize that they have the permission to do that thing, or else their actions will not federate.

Edit: Seems like this is a lemmy problem in general with quotation marks in the spoiler summary block. If you are on a lemmy instance and put this into the markdown, it will render the same way:

::: spoiler "Quotes" get garbled  
That summary above is messed up.  
:::  

So, this isn’t a PieFed issue at all, but something to do with lemmy’s markdown to html conversion improperly url-escaping quotes when it is in a <summary> tag.

Ok, I was really confused about this since I couldn’t reproduce this at all. However, this seems to only apply to quotes that are in a spoiler header. I made a codeberg issue for this.

viewing posts that aren’t in communities

Integrating microblogging more has been a common request in PieFed, but I keep running into this issue whenever I think about it. Posts belonging to a community are so integral to how the whole system works that undoing that is a huge lift.

I don’t know how much of a lift it might be from the UI side when consuming mbin’s API, but at least on the server side, this feature is likely to just be mbin for the foreseeable future.

Follow-up question: I am trying to get a feel for the “international hit” rule and how to apply it in this case. Anime is already a bit of a niche, but it can certainly break out into the mainstream, and I don’t want to contravene the spirit of this event by just choosing something that already hit it big so to speak.

My initial thought for an easy way to gauge this for our community is that videos over a view threshold should be excluded. An arbitrary value might be something like 10M or so. Looking over the award nominees from 2025 in the community for musical piece, that would exclude 3 of the 6 nominees.

Does that seem reasonable?

It’s really interesting that both season 1 and season 2 lasted almost exactly as long as one another. That is even after everybody got a second press within the first 24 hours to try to help carry it over until the button refresh happened. It really shows that there aren’t enough users active in that timezone to help it through to the next day.

Question: would the !anime@ani.social community be able to submit an anisong from this past year? That would be a song made for an anime show or movie.

Thanks for pointing this out. I am not that active on masto, but I am from the Boston area, so this might be the kick I need to check out that side of the fediverse. I lived in Somerville for 10 years before more recently moving to the burbs. I wouldn’t want to live anywhere else in this country these days.

Growing up in the US, other responders are correct that school systems vary a lot depending on what state/district you live in. Over the course of my K-12 education, I attended 10 different schools across three states because my family moved a lot. There were times where I would switch schools and suddenly be way ahead in some subject and have completely skipped over some other topics. As an example, I never took a course in world history, but ended up having three separate US history courses because the different districts taught those subjects in different grades.

I do take issue with some of the commenters painting all US schools with a broad brush as terrible. There are excellent schools in the US and excellent school systems. As an example, I currently live in Massachusetts, and if you took it as its own country, it would be one of the best school systems in the world. In general, the states that prioritize education and pay teachers well end up with better educational outcomes. It’s not that surprising really, but a huge portion of the country seems to ignore that fact or spend money in less efficient ways.

My Ph.D. is in rheology and material science. One of the craziest papers I ever remember reading was about the non-Newtonian behavior of frog tongues and saliva. I still think about this paper from time to time. There was a sequence of pictures showing a frog tongue (removed from the rest of the frog) lying on a table, and then somebody touching it with an ungloved finger and showing how sticky it was as they retracted their finger. What they won’t get poor grad students to do…

Link to the paper (pdf warning).