*we’ll know next month

The pancreas is not really stable enough to be implanted in at all. Other organs you’re imagining like liver, stomach, heart, etc. have a solid lining that can be cut open and stitched back together. The pancreas is more like a cluster of loose cells with veins throughout and held together by a very thin, tissue paper lining. If you try to open it and insert cells, you’re not going to be able to put it back together.

That’s why cells are usually put in the liver, which has a large vein going directly to the pancreas. Close proximity and high blood supply. Implanting in the pancreas will likely never be an option unless you can drastically reduce the volume of cells.

Our lab was working on implanting the stem cells on a porous scaffold in the fat pad of the stomach as an alternative

Unfortunately, that doesn’t necessarily negate the requirement for immunosuppresors or some other kind of immuno protection. If it is Type 1 diabetes, the person originally became diabetic because the immune system saw certain markers on the beta cells (insulin producing cells) as a threat. So, if you recreate the beta cells, there is still a possibility that it will happen again. You are fighting your own immune system. Someone in our lab was studying encapsulation of cells to create a protective barrier around them for this very issue

If the person was Type 2, this might be less of a risk since type 2 can also be due to high insulin resistivity. There are a lot of other factors involved, though, it’s not straightforward

I literally worked in a research lab working on islet cell therapies for diabetes in the US. This has actually been done many times before with cells from cadavers. It has been successful, although most the of the time the person reverts back after a few years

The issues we were trying to solve in the lab were

1. Finding a good place to transplant where the cells will last: Implanting in the hepatic region (liver), which is the most common place to implant, is toxic to the cells over time hence only lasting 3-5 years. The cells need a really good blood supply and the volume you’re transplanting can’t be easily transplanted in the pancreas or kidney capsules (where many successful studies were performed in mice and rats)

2. Being able to consistently make a high volume of stem cells that are fully grown into insulin producing cells: Cadaver cells usually require 3-5 donors for 1 person and require the receiver to be on lifelong immunosuppresors due to the immune response. Depending on the kind of stem cells, the patient may still even need immunosuppresors due to the cell type you’re converting from

All this the say - the article says nothing about where the cells where transplanted, where they came from, or whether the person has Type 1 or Type 2 diabetes. Although it is still a feat, it is likely not the first time it has been done, and we’re still a long ways off from a cure

Dr. Death was about gross negligence in medicine and the failure of the medical system to prevent unqualified doctors from making it through the system. There’s no evidence that this study has anything to do with that

Wubby7

None of those are mammals…

Don’t forget about all the Harold and Kumars, pineapple express, basically every other movie with Seth rogan, all the bill and Ted’s, Project x, role models, tropic thunder, horrible bosses, 21 jump street, etc. Some of these are also older, but I do think there are a lot more out there than you’re listing

Don’t give doctors a bad name like that. They work their asses off to help people and go many years being overworked and underpaid to do it

It’s the insurance companies that reap the benefits of people’s misfortune